49ers vs. Rams odds, spread, line: 2022 NFC Championship Game picks, predictions from top expert who’s 28-17

A trip to Super Bowl LVI is at stake when the San Francisco 49ers (10-7) and Los Angeles Rams (12-5) meet in the 2022 NFC Championship Game on Sunday. San Francisco has beaten Los Angeles six straight times dating back to 2019. The last time these two teams faced off came in Week 18. In that game, the 49ers rallied from a 17-0 deficit to secure a 27-24 win and punch their ticket to the postseason. The Niners also beat the Rams in Week 10, winning 31-10.

Kickoff from SoFi Stadium in Los Angeles is set for 6:30 p.m. ET. Los Angeles is a 3.5 point favorite and the over-under for total points scored is 45.5 in the latest 49ers vs. Rams odds from Caesars Sportsbook. Before locking in any Rams vs. 49ers picks of your own, you need to see what SportsLine’s resident Rams expert, Larry Hartstein, has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. This season he has been on fire. Hartstein is 73-48 in his last 121 NFL sides, for a profit of more than $1800. 

In addition, Hartstein has gone an astounding 28-17 in his last 45 picks involving Los Angeles, returning $800 to $100 bettors. Anyone who has followed him is way up. 

Now, Hartstein has locked in on 49ers vs. Rams and released a confident against-the-spread pick. You can only see his 2022 NFC Championship Game picks at SportsLine. Here are several NFL odds for 49ers vs. Rams: 

  • 49ers vs. Rams spread: Los Angeles -3.5 
  • 49ers vs. Rams over-under: 45.5 points 
  • 49ers vs. Rams money line: Los Angeles -180, San Francisco +155
  • LAR: Rams are 5-1 against the spread in their last six vs. NFC teams 
  • SF: 49ers are 4-0 ATS in their last four games as underdogs

Featured Game | Los Angeles Rams vs. San Francisco 49ers

Why the Rams can cover

Cooper Kupp was the best receiver in the NFL during the 2021 season. He led the league in receptions (145), receiving yards (1,947), and touchdowns (16). The Eastern Washington product is a silky smooth route-runner who consistently creates separation. Kupp had more than 100 yards in 11 regular-season outings.

The 2017 third-round pick has become quarterback Matthew Stafford’s favorite target and saw double-digit targets in 14 regular-season games. In the win over the Tampa Bay Buccaneers, Kupp had nine receptions for 183 yards with a score. The 2021 Pro-Bowl selection is the first player in NFL history to have 2,000-plus receiving yards in the regular season and playoffs combined. 

Why the 49ers can cover

San Francisco has defeated the Rams six straight times, dating back to 2019. The last time these two teams met was in Week 18. The 49ers came back from a 17-0 deficit to steal a 27-24 victory to clinch their postseason ticket. San Francisco’s team is filled with many dynamic players on both sides of the ball. Receiver Deebo Samuel is the ultimate Swiss Army knife for Kyle Shanahan’s offense. Samuel finished the year fifth in the NFL in receiving yards (1,405) with six touchdowns and 18.2 yards per reception.

The South Carolina product also sees plenty of action carrying the ball from the backfield and logged 365 rushing yards with another eight touchdowns. Defensive end Nick Bosa is consistently flying off the edge. He finished the year with 52 total tackles, 15.5 sacks, and 21 tackles for loss. The Ohio State product has already recorded 2.5 sacks this postseason. 

How to make 49ers vs. Rams picks

Hartstein has analyzed this matchup and while we can tell you he’s leaning under on the point total, he has also discovered a crucial x-factor that makes one side of the spread a must-back. He’s only sharing what it is, and which side of the Rams vs. 49ers spread to back, at SportsLine.

Who wins Rams vs. 49ers? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Rams vs. 49ers spread to jump on, all from the NFL expert who’s 28-17 on picks involving the Rams, and find out. 

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