UFC 264: McGregor vs. Poirier predictions, odds, picks: Best bets on the fight card from seasoned MMA expert

It’s quite rare for a numbered UFC event to not have a main event title fight, but having a fighter with the magnitude of Conor McGregor is also quite rare. The former lightweight champion will step back into the Octagon at UFC 264 for just his fourth fight since November 2016. He will match up with fellow lightweight Dustin Poirier for a rubber match after the two split their first two encounters, with McGregor winning in 2014 and Poirier getting revenge earlier this year. Poirier vs. McGregor 3 highlights the UFC 264 fight card and will take place from T-Mobile Arena in Las Vegas this Saturday. The main UFC 264 card starts at 10 p.m. ET.

McGregor is priced at -115 (risk $115 to win $100), while Poirier is +105 in the latest Conor McGregor vs. Dustin Poirier odds from William Hill Sportsbook. In the co-main event, welterweights take the spotlight as Stephen Thompson (-155) faces Gilbert Burns (+130). Before finalizing any McGregor vs. Poirier picks or UFC 264 predictions, make sure you check out the expert MMA picks from SportsLine’s Kyle Marley.

Over the past 28 months, $100 bettors who have followed Marley’s picks are up more than $15,000. The accomplished MMA analyst has seen memorable run in 2020 carry over into 2021. He has now nailed 32 of his last 52 UFC main-event picks, a stretch that included a streak of five consecutive underdogs.

At UFC Fight Night last weekend, Marley’s winners included Shavkat Rakhmonov over Michel Prazeres and Tim Means over Nicolas Dalby, both in welterweight bouts. Anyone who has followed Marley is way up. 

Now, Marley has made the call on Poirier vs McGregor 3 and every other matchup on the UFC 264 fight card. You can only see who to back here.

Conor McGregor vs. Dustin Poirier expert preview

Poirier has been at or near the top of his game and is No. 1 in the latest UFC lightweight rankings. Including his TKO win over McGregor in January, he has won 11, lost two and had one no contest since April 2015. Just two of Poirier’s fights have lasted five rounds and he has won 13 by knockout, seven by submission and seven by decision. His last bout that lasted five rounds was in June of last year, when he defeated Dan Hooker by unanimous decision.

McGregor was knocked out for the first time in his career when Poirier stopped him at 2:32 of the second round at UFC 257 in January. McGregor has an aggressive style and prefers to fight upright rather than use his wrestling skills. McGregor tried his hand in the boxing ring, losing his only professional boxing match in August 2017. Floyd Mayweather Jr. stopped him by TKO at 1:05 of the 10th round.

McGregor, who more recently floated the idea of retirement, has posted a 22-5 career MMA mark, winning 19 matches by knockout. He is a former UFC featherweight and lightweight double-champion and fifth in the most recent UFC lightweight rankings. He once won 15 straight bouts spanning four years, but his streak ended in his welterweight debut when he lost by submission to Nate Diaz at UFC 196. He avenged that defeat by winning a major decision over Diaz at UFC 202 in August 2016. You can see which McGregor vs. Poirier picks to make for the fight here.

UFC 264: Conor McGregor vs. Dustin Poirier predictions

We’ll share one of Marley’s UFC 264: McGregor vs. Poirier 3 selections here: He is going with Trevin Giles (-110) to get his hand raised against Dricus Du Plessis (-110) in a matchup of middleweight prospects.

Giles (14-2), a Houston police officer, made his UFC debut in 2014, winning by submission over Angelus Raymond McFarlane at Legacy FC 27. He won his first 11 fights of his career before suffering his only two losses of his career in 2019, both by submission. Since that time, he has won his last three fights, including a unanimous decision over Roman Dolidze in March.

Du Plessis (15-2) has also won his last three bouts, including a win by knockout over Markus Perez in October of last year. This will be his first fight in nine months. Prior to the coronavirus pandemic, Du Plessis won the EFC Middleweight Championship in December 2019, when he defeated Brendan Lesar by submission at EFC Africa 83. 

“I am going to take Giles to be the aggressor and the one landing the better strikes and takedowns and he can win a decision or get a finish himself,” Marley told SportsLine. 

How to make UFC 264: Conor McGregor vs. Dustin Poirier picks

Marley also has strong picks for McGregor vs. Poirier and every other fight on the UFC 264 fight card. He’s also backing a fighter who’s coming in hot to pull off a decision win. You can only get those UFC 264 picks at SportsLine.

Who wins Conor McGregor vs. Dustin Poirier? And how exactly does each fight end? Visit SportsLine now to get detailed picks on every fight at UFC 264, all from the expert who’s up more than $15,000 on MMA in the past 28 months, and find out.

UFC 264 odds, fight card

Dustin Poirier (-105) vs. Conor McGregor (-115)  
Stephen Thompson (-140) vs. Gilbert Burns (+120)  
Tai Tuivasa (-140) vs. Greg Hardy (+120)  
Irene Aldana (-145) vs. Yana Kunitskaya (+125)  
Sean O’Malley (-800) vs. Kris Moutinho (+550)  
Max Griffin (-175) vs. Carlos Condit (+155)  
Michel Pereira (-160) vs. Niko Price (+140)  
Trevin Giles (-120) vs. Dricus du Plessis (+100)  
Ilia Topuria (-240) vs. Ryan Hall (+200)  
Jennifer Maia (-190) vs. Jessica Eye (+170)  
Brad Tavares (-175) vs. Omari Akhmedov (+155)  
Zhalgas Zhumagulov (-400) vs. Jerome Rivera (+320)  
Alen Amedovski (-175) vs. Yaozong Hu (+155) 

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